Why GLP 1 Medications Cause Constipation and How to Find Relief

GLP 1 receptor agonists like semaglutide, tirzepatide, Ozempic, Wegovy, and Mounjaro have become powerful tools for weight loss and metabolic health. These medications work by mimicking a natural hormone called GLP 1, which plays a key role in blood sugar control, appetite regulation, and digestion.

GLP 1 acts in several ways:

• In the brain, it helps reduce hunger signals and quiets food noise, the constant mental chatter around eating
• In the gut, it slows gastric emptying, which prolongs the feeling of fullness
• This slower digestion contributes to weight loss, but it can also lead to constipation by increasing intestinal transit time

Constipation is one of the most common side effects of GLP 1 medications. If left unaddressed, it can become uncomfortable and impact adherence to therapy. Fortunately, there are effective strategies to improve gut motility and support regular bowel movements.

Proven Ways to Relieve Constipation on GLP 1 Medications

1. Increase Fiber Intake

Fiber helps bulk up stool and support regularity. Focus on soluble fiber from fruits, vegetables, legumes, chia seeds, and oats. Gradually increase fiber to prevent bloating.

2. Stay Well Hydrated

When increasing fiber, hydration is essential. Drinking enough water keeps stools soft and helps move waste through the intestines.

3. Move Your Body

Physical activity stimulates digestion and bowel motility. Encourage daily movement, such as walking or light exercise, to support regularity.

4. Use Stool Softeners or Laxatives if Needed

For persistent constipation, temporary use of stool softeners or laxatives can be helpful. These should be used under the guidance of your healthcare provider and are not meant for long-term use.

5. Add Probiotics

Healthy gut bacteria influence digestion. Consider probiotic-rich foods like kefir, sauerkraut, kimchi, or a high-quality probiotic supplement to support a balanced microbiome.

6. Eat Smaller, More Frequent Meals

Large meals can overwhelm a slowed digestive system. Eating smaller portions throughout the day can ease digestion and reduce constipation.

7. Consider Magnesium Supplements

Low-dose magnesium citrate can help draw water into the colon, softening stool and promoting regular bowel movements. Always consult your physician before starting supplements.

Supporting Success on GLP 1 Therapy

Constipation is a manageable side effect of GLP 1 therapy. With the right support, most patients find relief and continue seeing positive results from these medications. By addressing gut health and digestion early, patients are more likely to stay consistent and reach their long-term health goals.

At Ace Longevity, we combine precision medicine, functional medicine, and a highly personalized approach to help patients thrive on their GLP 1 journey.